SRS1 Software, LLC is a Newton, MA based software company that provides software and digital imaging products and services.Mutagenesis targeted to unblock the steric. In this work, we identified an active tunnel for substrate access and product release of an epoxide hydrolase with unusual ( R )-enantioselectivity. The enzymatic production of bulky epoxides has proven remarkably challenging. Application of epoxide hydrolases in synthesizing chiral drug compounds has been hindered by their limited substrate range.
